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Synlett 1999; 1999(S1): 1000-1002
DOI: 10.1055/s-1999-3119
DOI: 10.1055/s-1999-3119
letter
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Synthesis of Two Novel Cyclic Biphenyl Ether Analogs of an Inhibitor of HCV NS3 Protease
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/1999Sup1/lookinside/thumbnails/10.1055-s-1999-3119-1.jpg)
The synthesis of two cyclic ether analogs of a tetrapeptide inhibitor of the hepatitis C virus NS3 protease has been carried out using intramolecular nucleophilic aromatic substitution (SNAr) reactions of ruthenium π-aryl complexes of pre-assembled tripeptides.
hepatitis C - NS3 protease - enzyme inhibitor - cyclic ether - nucleophilic aromatic substitution