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Synlett 1999; 1999(S1): 1000-1002
DOI: 10.1055/s-1999-3119
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Synthesis of Two Novel Cyclic Biphenyl Ether Analogs of an Inhibitor of HCV NS3 Protease

Antonella Marchetti* , Jesus M. Ontoria, Victor G. Matassa
  • *Department of Chemistry, Istituto di Ricerche di Biologia Molecolare (IRBM) P. Angeletti, Via Pontina Km 30.600, Pomezia, Rome, 00040 Italy; Fax +39(6)91 09 36 54; E-mail: matassa@irbm.it
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Publication Date:
31 December 1999 (online)

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The synthesis of two cyclic ether analogs of a tetrapeptide inhibitor of the hepatitis C virus NS3 protease has been carried out using intramolecular nucleophilic aromatic substitution (SNAr) reactions of ruthenium π-aryl complexes of pre-assembled tripeptides.

hepatitis C - NS3 protease - enzyme inhibitor - cyclic ether - nucleophilic aromatic substitution