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Synlett 1999; 1999(S1): 917-920
DOI: 10.1055/s-1999-3117
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Interactions of Amino Acid Side Chains with Nucleobases in Alanyl-PNA

Ulf Diederichsen* , Daniel Weicherding
  • *Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany; Fax +49(89)28 91 32 10; E-mail: Diederichsen@ch.tum.de
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Publication Date:
31 December 1999 (online)

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Alanyl peptide nucleic acid double strands represent a rigid and well defined model system for stacking nucleobase pairs. They serve as an important tool to study hydrogen bonding, van der Waals interactions, stacking and solvent effects between the amino acid side chains and nucleobases. Covalently linked dyes were brought in proximity to the base stack without influencing conformational reorganization of the backbone.

amino acids - hydrogen bond - intercalator - nucleobase stacking - peptide nucleic acid (PNA)