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Synlett 1999; 1999(S1): 997-999
DOI: 10.1055/s-1999-3116
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Synthesis of 3-Alkoxy- and 3-Alkylamino-2-alkyl-3-arylisoindolinones

Martin S. Kitching* , William Clegg, Mark R. J. Elsegood, Roger J. Griffin, Bernard T. Golding
  • *Department of Chemistry, Bedson Building, The University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, UK; Fax +44(1 91)2 22 69 29; E-mail: b.t.golding@ncl.ac.uk
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Publication Date:
31 December 1999 (online)

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Solvent-controlled regioselectivity in the reactions of 3-chloroisoindolinones with primary amines allows the rational synthesis of isoindolinones by a route suitable for parallel combinatorial chemistry.

isoindolinones - regioselectivity - solvent effect - combinatorial synthesis