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Synlett 1999; 1999(S1): 981-983
DOI: 10.1055/s-1999-3108
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Characterization of Caged Cholinergic Ligands; Sulfonated Calix[4]arene Inclusion Complexes

Alexandre Specht* , Maurice Goeldner, Jakob Wirz, Ling Peng
  • *Laboratoire de Chimie Bio-organique, CNRS UMR 7514 - Faculté de Pharmacie, Université Louis Pasteur Strasbourg, B.P. 24, F-67401 Illkirch, France; Fax +33(3)88 67 88 91; E-mail: peng@bioorga.u-strasbg.fr
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Publication Date:
31 December 1999 (online)

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p-Tetrasulfonated calix[4]arene, a simple prototype of an artificial cholinergic receptor, binds strongly "caged" cholinergic ligands forming host-guest complexes with binding constants below 100 μM. Photoirradiation of the host-guest complexes gave the desired fragmentation reactions releasing the cholinergic ligands. Remarkably, the kinetics of photorelease of cholinergic ligands from the host-guest complex is similar to that obtained with caged cholinergic ligands alone.

host-guest inclusion chemistry - caged cholinergic ligands - artificial cholinergic receptor - calixarene - laser flash photolysis