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Synlett 1999; 1999(S1): 978-980
DOI: 10.1055/s-1999-3107
DOI: 10.1055/s-1999-3107
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Synthesis of an RNA-Peptide Conjugate by Orthogonal Ligation
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Publikationsverlauf
Publikationsdatum:
31. Dezember 1999 (online)
![](https://www.thieme-connect.de/media/synlett/1999Sup1/lookinside/thumbnails/10.1055-s-1999-3107-1.jpg)
A convergent strategy for the synthesis of an RNA-peptide conjugate is presented. Regioselective ligation between a 5′-modified RNA harboring a 5′-thioester group and a peptide carrying an N-terminal cysteine afforded an RNA-peptide conjugate under physiological conditions without the need for protecting groups.
encoded peptide library - RNA-peptide conjugate - orthogonal ligation - nucleic acid-protein conjugate