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Synlett 1999; 1999(S1): 889-892
DOI: 10.1055/s-1999-3102
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4-Diazocyclohexa-2,5-dienone Derivatives as Photoaffinity Labels for Proteins: Scope and Limitations

Christophe Colas* , Thomas Grutter, Maurice Goeldner
  • *Lab. de Chimie Bioorganique, UMR 7514 CNRS, Faculté de Pharmacie, Université L. Pasteur Strasbourg, BP 24, 67401 Illkirch Cedex France; Fax +33(3)88 67 88 91; E-mail: goelder@bioorga.u-strasbg.fr
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Publication Date:
31 December 1999 (online)

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4-Diazocyclohexa-2,5-dienone derivatives are presented as photosensitive reagents generating reactive carbene species which allow efficient photo-coupling reactions with proteins. However, during such coupling reactions, the photogenerated hydroquinones can initiate undesired redox side reactions.

photochemistry - carbenes - hydroquinones - redox reaction

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