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Synlett 1999; 1999(S1): 865-866
DOI: 10.1055/s-1999-3094
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An Alternative Synthesis of a Potent GPIIb/IIIa Receptor Antagonist

Jerome F. Hayes*
  • *SmithKline Beecham Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, Kent, TN11 9AN, England
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Publication History

Publication Date:
31 December 1999 (online)

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A key intermediate to SB-214857 was prepared via an oxidative cyclization of a hydroquinone with a flanking aspartate side chain using Fremy's salt.

benzodiazepine - cyclization - quinone - hydroquinone - oxidation