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Synlett 1999; 1999(S1): 873-876
DOI: 10.1055/s-1999-3091
DOI: 10.1055/s-1999-3091
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
A Second-Generation Cycloaddition Route to 5-Substituted 3-Acyltetramic Acids
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/1999Sup1/lookinside/thumbnails/10.1055-s-1999-3091-1.jpg)
The 1,3-dipolar cycloaddition of α-aminonitrile oxides, formed from α-amino-acids, to enamines of β-ketoesters affords 3-(1-aminoalkyl)isoxazole-4-carboxylic esters that are converted via pyrrolo[3,4-c]isoxazol-4-ones into 5-substituted 3-acetyltetramic acids.
acyltetramic acid - isoxazole - nitrile oxide - dipole - cycloaddition