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Synlett 1999; 1999(S1): 954-956
DOI: 10.1055/s-1999-3088
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A Bromoarene Based Approach to Phenylalanine Analogues Hic and Nic

Susan E. Gibson* , Jerome O. Jones, Ray McCague, Matthew J. Tozer, Nicole J. Whitcombe
  • *Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London SW7 2AY, UK; E-mail: s.gibson@kcl.ac.uk
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Publikationsdatum:
31. Dezember 1999 (online)

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A Heck reaction system incorporating Ph4PCl and using bromoarenes as substrates has enabled the syntheses of the conformationally constrained phenylalanine analogoues Hic and Nic to be dramatically shortened thus facilitating the production of significant quantities of these amino acids.

amino acid synthesis - Heck reaction - phenylalanine analogues - cyclisation - palladium catalysis