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Synlett 1999; 1999(12): 1915-1916
DOI: 10.1055/s-1999-2992
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A Concise Synthesis of (-)-Cytoxazone and its Stereoisomers via Imino 1,2-Wittig Rearrangement

Okiko Miyata* , Hiroshi Asai, Takeaki Naito
  • *Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan; Fax + 81 78 4 41 75 56; E-mail: taknaito@kobepharma-u.ac.jp
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Publication Date:
31 December 1999 (online)

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A concise synthesis of (-)-cytoxazone (1) and its stereoisomers has been achieved via the route involving the imino 1,2-Wittig rearrangement of hydroximate.

hydroximate - Wittig rearrangement - 2-hydroxy oxime ether - oxazolidinone - cytokine modulator

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