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Synlett 1999; 1999(12): 1899-1902
DOI: 10.1055/s-1999-2989
DOI: 10.1055/s-1999-2989
letter
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BINOL-Ti-Catalyzed Carbonyl-Ene Cyclization by Tuning the 6-Br-Ligand for the Synthesis of 2-Methyl-19-nor-22-oxa Vitamin D Analogue with Significant Differentiation Activity
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Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199912/lookinside/thumbnails/10.1055-s-1999-2989-1.jpg)
Transition state control in BINOL-Ti-catalyzed asymmetric carbonyl-ene cyclization by tuning the 6-Br-BINOL ligand completes the synthesis of the A ring of the 2-methyl-19-nor-22-oxa D3 analogue (2), which shows the significant activity in differentiation of HL-60 cell.
vitamin D - ene reaction - binaphthol - titanium complex - asymmetric catalysis