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Synlett 1999; 1999(12): 1919-1920
DOI: 10.1055/s-1999-2982
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A Concise, Asymmetric Synthesis of Methyl (1S,2R)-1-Amino-2,3-dihydro-1H-indene-2-carboxylate: A Novel, Constrained β-Amino Ester

David A. Price*
  • *Department of Discovery Chemistry, Pfizer Central Research, Sandwich, Kent, CT13 9NJ, UK; Fax + 44(0 13 04)65 84 22; E-mail: david_a_price@sandwich.pfizer.com
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Publication Date:
31 December 1999 (online)

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The concise, asymmetric synthesis of methyl (1S,2R)-1-amino-2,3-dihydro-1H-indene-2-carboxylate is reported using a novel tandem conjugate addition, intramolecular electrophilic trap to construct the indane skeleton.

β-amino acid - conjugate addition - lithium amide - cinnamate - ester enolate