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Synlett 1999; 1999(12): 1907-1910
DOI: 10.1055/s-1999-2973
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Asymmetric Aminohydroxylation of Heteroaromatic Acrylates

Dirk Raatz* , Clara Innertsberger, Oliver Reiser
  • *Institut für Organische Chemie der Universität Regensburg, Universitätsstr. 31, D-93040 Regensburg, Germany
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Publikationsdatum:
31. Dezember 1999 (online)

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N-, S- and O-heteroaromatic acrylates were aminohydroxylated with generally high regio- and enantioselectivity. While pyridylacrylates are not amenable towards this process, the corresponding N-oxides proved to be a useful substitute, allowing the access to biologically important pyridine substituted taxolTM side chain analogs.

aminohydroxylations - amino acids - asymmetric catalysis - taxolTM (paclitaxel) - pyridines