PDF herunterladen
Synlett 1999; 1999(12): 1972-1974
DOI: 10.1055/s-1999-2963
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Concise Synthesis of N-(Trideuteromethyl)morpholine-N-oxide Monohydrate

Thomas Rosenau* , Antje Potthast, Paul Kosma
  • *Christian-Doppler-Laboratory, University of Agricultural Sciences - Vienna, Muthgasse 18, A-1190 Vienna, Austria; Fax + 43 13 60 06 60 59; E-mail: pkosma@edv2.boku.ac.at
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 1999 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

An efficient synthesis of N-(trideuteromethyl)morpholine-N-oxide monohydrate (3) is described. The procedure applies the tocopheryl protecting group, and makes use of sodium percarbonate as the oxidant and water donor, thus avoiding both the troublesome direct alkylation of morpholine and the unsuitable oxidation by aqueous hydrogen peroxide. Overall yields of purified material range above 90%.

N-methylmorpholine-N-oxide - amine oxides - sodium percarbonate - Toc protecting group