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Synlett 1999; 1999(11): 1784-1786
DOI: 10.1055/s-1999-2944
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Monofunctionalization of Calix[4]arene Tetracarboxylic Acid at the Upper Rim with Isothiocyanate Group: First Bifunctional Chelating Agent for Alpha-Emitter Ac-225

Xiaoyuan Chen* , Xiaoyuan Chen1 , Min Ji, Darrell R. Fisher, Chien M. Wai
  • *Department of Chemistry, University of Idaho, Moscow, ID 83844-2343, USA
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Publication Date:
31 December 1999 (online)

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A procedure is reported for synthesizing a novel, water-soluble bifunctional chelating agent derived from calix[4]arene. This chelate features tetracarboxylic acid groups at the lower rim as an actinium-225 ionophore, and an isothiocyanate functional group at the upper rim for labeling of the N-terminus of monoclonal antibodies through thiourea linkage.

actinium-225 - bifunctional chelating agents - calixarenes - isothiocyanate

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