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Synlett 1999; 1999(11): 1829-1831
DOI: 10.1055/s-1999-2938
DOI: 10.1055/s-1999-2938
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
A New Method for the Synthesis of 5-Fluorouracil Prodrugs
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Publikationsverlauf
Publikationsdatum:
31. Dezember 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199911/lookinside/thumbnails/10.1055-s-1999-2938-1.jpg)
Bromo-tris(dimethylamino)-phosphonium-hexafluorophosphate (BROP) is a particularly suitable reagent for synthesising some 5-fluorouracil prodrugs in a one step reaction. Several acids, especially retinoic acid, were bound to the N1 of 5-fluorouracil, with yields of about 50% after purification.
N1-retinoyl-5-fluorouracil - BROP - artificial nucleosides - prodrug