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Synlett 1999; 1999(11): 1829-1831
DOI: 10.1055/s-1999-2938
DOI: 10.1055/s-1999-2938
letter
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A New Method for the Synthesis of 5-Fluorouracil Prodrugs
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199911/lookinside/thumbnails/10.1055-s-1999-2938-1.jpg)
Bromo-tris(dimethylamino)-phosphonium-hexafluorophosphate (BROP) is a particularly suitable reagent for synthesising some 5-fluorouracil prodrugs in a one step reaction. Several acids, especially retinoic acid, were bound to the N1 of 5-fluorouracil, with yields of about 50% after purification.
N1-retinoyl-5-fluorouracil - BROP - artificial nucleosides - prodrug