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Synlett 1999; 1999(11): 1747-1748
DOI: 10.1055/s-1999-2929
DOI: 10.1055/s-1999-2929
letter
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The Microwave Assisted Nucleophilic Substitution of 4-Hydroxy-6-methyl-2(1H)-pyridones
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Publication History
Publication Date:
31 December 1999 (online)
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The condensation of 4-hydroxy-6-methyl-2(1H)-pyridones 1 with araliphatic amino compounds 2 gives rise to the 4-alkylamino-6-methyl-2(1H)-pyridones 3. Irradiation using an ordinary domestic microwave oven provides a fast and simple method for their preparation. However, under the conditions used, aliphatic and aromatic amines gave no reaction
4-alkylamino-6-methyl-2(1H)-pyridones - microwave irradiation - condensation