A New Device for Abrasive Cytology Sampling During Upper Gastrointestinal Endoscopy: Experience in Infectious and Neoplastic Diseases

Introduction

The quantity and variety of neoplastic and infectious pathologies which the endoscopist faces - and which have increased as a result of immunosuppression treatment, organ transplantation, chemotherapy, and acquired immune deficiency syndrome (AIDS) - have made it necessary to develop and apply simple, accurate, fast and low-cost methods that can easily be incorporated into routine endoscopy [1]. Various endoscopic treatment decisions would also benefit from the availability of fast diagnostic techniques that can ensure good-quality samples and provide better access to stenotic processes. We have developed a fast method that may help diagnose a variety of infectious processes in the gastrointestinal mucosa by identifying their etiology in a simple way. In addition, the technique can allow immediate diagnosis of endoscopically suspected neoplastic disease, so that treatment decisions can be taken without delay.

Abrasive cytological sampling is carried out at our institution using a new method of diagnosing neoplastic and infectious diseases, and the present report describes the cytological and histological findings in patients suffering from immunosuppression and neoplastic disease.

References

• 1 Muñoz E, Carmona T, Chavez F, et al. Identification of Giardia lamblia by gastric brush cytology.  Acta Cytol. 1996;  40 1331-2
• 2 Murty A, Lutthra U, Sengal K, et al. Cytologic detection of Strongyloides stercoralis in routine cervicovaginal smear: a case report.  Acta Cytol. 1994;  38 323-52
• 3 Huang MS, Wang WN, Wud C, et al. Utility of brushing cytology in the diagnosis of Helicobacter pylori infection.  Acta Cytol. 1996;  40 714-8
• 4 Koneman E, Aliens S, Janda W, et al. Parasitology.  New York:; Lippincott-Raven, 1997: 1093-9
• 5 Schwartz D, Sobottica I, Leitch G, Vivesvara J. Pathology of microsporidiosis: emerging parasitic infections in patients with acquired immunodeficiency syndrome.  Arch Pathol Lab Med. 1996;  120 173-88
• 6 Binford CH, Connor DH. Pathology of tropical and extraordinary diseases.  Washington, DC; Armed Forces Institute of Pathology 1976
• 7 Bini EJ, Cohen J. Cost-effectiveness of endoscopy in HIV-positive patients with chronic diarrhea abstract.  Gastrointest Endosc. 1997;  45 A45
• 8 Wang HH, Jonasson J, Ducatman B. Brushing cytology of the upper gastrointestinal tract: obsolete or not?.  Acta Cytol. 1991;  35 195-8
• 9 Malthotra V, Puri R, Chinna RS, et al. Endoscopic techniques in the diagnosis of upper gastrointestinal tract malignancies: a comparison.  Acta Cytol. 1996;  40 929-32
• 10 Shurbaji M, Erzan Y. The cytopathologic diagnosis of esophageal adenocarcinoma.  Acta Cytol. 1991;  35 189-94