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Synlett 1999; 1999(9): 1426-1428
DOI: 10.1055/s-1999-2872
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One-pot Mannich-Type Reaction In Water: HBF4 Catalyzed Condensation of Aldehydes, Amines, and Silyl Enolates for the Synthesis of β-Amino Carbonyl Compounds

Takahiko Akiyama* , Jun Takaya, Hirotaka Kagoshima
  • *Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan; Fax + 81-3-59 92-10 29; E-mail: takahiko.akiyama@gakushuin.ac.jp
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Publication History

Publication Date:
31 December 1999 (online)

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HBF4 catalyzed Mannich-type reactions of aldehydes, amines, and silyl enolates took place smoothly in water in the presence of a surfactant to afford β-amino carbonyl compounds in high yields.

Mannich-type raction - water - HBF4 - surfactant - aldimine