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Synlett 1999; 1999(9): 1401-1402
DOI: 10.1055/s-1999-2871
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A Brønsted Acid-Surfactant-Combined Catalyst for Mannich-Type Reactions of Aldehydes, Amines, and Silyl Enolates in Water

Kei Manabe* , Yuichiro Mori, Shū Kobayashi
  • *Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
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Publication Date:
31 December 1999 (online)

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Three-component Mannich-type reactions of aldehydes, amines, and silyl enolates in water were successfully carried out in the presence of dodecylbenzenesulfonic acid as a Brønsted acid-surfactant-combined catalyst.

Brønsted acid - Mannich reaction - surfactant - sulfonic acid - silyl enolate

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