Synlett 1999; 1999(9): 1495-1507
DOI: 10.1055/s-1999-2865
new tools in synthesis
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Glycoprotein Synthesis: From Glycobiological Tools to Tailor-made Catalysts

Benjamin G. Davis* , J. Bryan Jones
  • *Department of Chemistry, University of Durham, South Road, Durham DH1 3LE, UK; Fax + 44 191 3 84 47 37; E-mail: Ben.Davis@durham.ac.uk
Further Information

Publication History

Publication Date:
31 December 1999 (online)

The synthesis of pure, well-defined glycoproteins is essential to the study of the host of biological processes that they mediate. The use of a combined site-directed mutagenesis and chemical modification strategy allows the site-selective synthesis of homogeneous glycoproteins, the determination of precise structure-activity relationships and the design of new synthetic catalysts. This general and powerful method is reviewed in the context of existing preparative techniques and the wide-ranging applications of glycoproteins are highlighted

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