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Synlett 1999; 1999(9): 1438-1440
DOI: 10.1055/s-1999-2863
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Application of a New Solid-Phase Resin: Benzamide ortho-Lithiation and the Synthesis of a Phthalide Library

Patrick Garibay* , Patrick H. Toy, Thomas Hoeg-Jensen, Kim D. Janda
  • *Novo Nordisk A/S, Novo Alle 6BS.58, DK-2800 Bagsvaerd, Denmark
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Publication Date:
31 December 1999 (online)

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The utility of new polytetrahydrofuran cross-linked polystyrene resins is demonstrated through the solid-phase synthesis of a phthalide library. The phthalides are synthesized via directed ortho-lithiation of resin bound benzamides and isolated via cyclative cleavage.

solid-phase synthesis - resin - ortho-lithiation - phthalide