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Synlett 1999; 1999(9): 1395-1396
DOI: 10.1055/s-1999-2860
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An Enantioselective Formal Total Synthesis of Phytuberin

George A. Kraus* , Xuemei Wang
  • *Department of Chemistry, Iowa State University, Ames, IA 50011, USA; Phone: + 1(5 15)2 94 63 42; Fax + 1(5 15)2 94 01 05; E-mail: gakraus@iastate.edu
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Publication Date:
31 December 1999 (online)

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A formal total synthesis of phytuberin was achieved in eight steps from carvone. The key transformations were the alkoxide-directed addition of dichloromethyl lithium and the alkoxide-mediated hydrolysis of the dichloromethyl carbinol.

dichloromethyl lithium - dichloromethyl carbinol