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Synlett 1999; 1999(9): 1371-1374
DOI: 10.1055/s-1999-2858
DOI: 10.1055/s-1999-2858
letter
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Asymmetric Synthesis of Mercaptoalcohols - Matrix Metalloproteinase Inhibitors
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199909/lookinside/thumbnails/10.1055-s-1999-2858-1.jpg)
A novel approach has been developed for the preparation of all of the possible diastereoisomers of mercaptoalcohol 1, a potent matrix metalloproteinase (MMP) inhibitor, with easy access to various P1′ substituents. Readily available chiral epoxides have been used as the starting materials to control the stereochemistry of the -OH group.
Mercaptoalcohol - MMP inhibitor - malonate alkylation - epoxide opening - decarboxylation