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Synlett 1999; 1999(6): 765-767
DOI: 10.1055/s-1999-2712
DOI: 10.1055/s-1999-2712
letter
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Enantioselective Synthesis of (R)- and (S)-Cizolirtine; Application of Oxazaborolidine-Catalyzed Asymmetric Borane Reduction to Azolyl Phenyl Ketones
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Publikationsdatum:
31. Dezember 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199906/lookinside/thumbnails/10.1055-s-1999-2712-1.jpg)
An efficient enantioselective synthesis of (R)- and (S)-cizolirtine 1 is described. The key step of the procedure is the CBS-oxazaborolidine asymmetric reduction of phenyl pyrazolyl ketone 2. Related enantioselective reductions of several azolyl phenyl ketones are also reported.
asymmetric synthesis - cizolirtine - oxazaborolidine - azolyl phenyl ketones - enantioselective reduction