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Synlett 1999; 1999(4): 471-473
DOI: 10.1055/s-1999-2643
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Alternatives to Vinyl Triflates for Cross-Coupling with Arylboronic Acids

Mark A. Huffman* , Nobuyoshi Yasuda
  • *Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065; E-mail: mark_huffman@merck.com
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Publication History

Publication Date:
31 December 1999 (online)

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Vinyl phosphates, mesylates, and tosylates derived from 1,3-dicarbonyl compounds are coupled with phenylboronic acid using nickel or palladium catalysts. An application to the area of 2-aryl carbapenem antibiotics is demonstrated. Alternative conditions for the nickel-catalyzed coupling of aryl mesylates are also reported.

cross-coupling - boronic acid - carbapenem - palladium - nickel