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Synlett 1999; 1999(4): 456-458
DOI: 10.1055/s-1999-2639
DOI: 10.1055/s-1999-2639
letter
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A Highly Efficient Synthesis of 1-Alkylidene-1,3-Dihydroisobenzofurans and 3-Alkylidene Isobenzofuran-1 (3H)-ones(phthalides) through Palladium-Copper Catalysis using Acetylenic Carbinols als Synthons
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Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199904/lookinside/thumbnails/10.1055-s-1999-2639-1.jpg)
The reaction of o-iodobenzyl alcohol with various acetylenic carbinols with a terminal acetylenic group in the presence of a palladium catalyst leads to E-1-alkylidene-1,3-dihydroisobenzofurans as the exclusive products which were converted readily to E-3-alkylidene phthalides by Jones oxidation.
isobenzofurans - phthalides - palladium catalysis - acetylenic carbinols