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Synlett 1999; 1999(3): 357-359
DOI: 10.1055/s-1999-2617
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Selective Deprotection of Triethylsilyl Group in the Presence of t-Butyldimethylsilyl Group with MCM-41/MeOH Heterogeneous System

Akichika Itoh* , Tomohiro Kodama, Yukio Masaki
  • *Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502, Japan; Fax +81-58-2 37-59 79; E-mail: masaki@gifu-pu.ac.jp
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Publication Date:
31 December 1999 (online)

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Triethylsilyl (TES) group of silyl ethers of several types is selectively and easily removed in the presence of t-butyldimethylsilyl group (TBS) with a mesoporous silica MCM-41/MeOH heterogeneous system. Comparison of the efficiency was carried out among several solvents, and among such promoters as common zeolites and ion-exchange resins.

selective deprotection - triethylsilyl - t-butyldimethylsilyl - MCM-41 - heterogeneous