Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1999; 1999(3): 291-294
DOI: 10.1055/s-1999-2594
DOI: 10.1055/s-1999-2594
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Novel Tocopherol Compounds XI. Synthesis, Bromination and Oxidation Reactions of 3-(5-Tocopheryl)propionic Acid
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199903/lookinside/thumbnails/10.1055-s-1999-2594-1.jpg)
3-(5-Tocopheryl)propionic acid (γ-tocopherol-5-propionic acid, 13) has been synthesized by a multi-step sequence involving the hetero-Diels-Alder reaction between O-methyl-C,O-bis-(trimethylsilyl)ketene acetal (10) and the ortho-quinone methide of α-tocopherol (5) as the key step. The title compound is the first 5a-substituted tocopherol that shows an oxidation behavior largely similar to α-tocopherol.
α-tocopherol - 5a-substituted tocopherols - ortho-quinone methide - ketene acetal - hetero-Diels-Alder reaction