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Synlett 1999; 1999(2): 193-194
DOI: 10.1055/s-1999-2584
DOI: 10.1055/s-1999-2584
letter
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A Convenient Synthesis of Disubstituted Guanidines via the Mitsunobu Protocol
Further Information
Publication History
Publication Date:
31 December 1999 (online)
![](https://www.thieme-connect.de/media/synlett/199902/lookinside/thumbnails/10.1055-s-1999-2584-1.jpg)
An efficient synthetic method for the preparation of disubstituted guanidines is described. Primary and secondary alcohols were treated with guanylating agents under Mitsunobu conditions and their subsequent reactions with amines provided disubstituted guanidines.
disubstituted guanidines - Mitsunobu reaction - monoalkylated guanylating agents