Synlett 1999; 1999(2): 189-192
DOI: 10.1055/s-1999-2578
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Synthetic Route To Macrocyclic cis-3-Phenylproline Derivatives as Mimics of Sandostatin®

Dominique Damour* , Gilles Doerflinger, Guy Pantel, Richard Labaudinière, Jean-Pierre Leconte, Serge Sablé, Marc Vuilhorgne, Serge Mignani
  • *Rhône-Poulenc Rorer SA, Centre de Recherche de Vitry-Alfortville, 13 Quai Jules Guesde-BP 14, 94403, Vitry-sur-Seine Cedex, France; Fax 33(1)55 71 80 63; E-mail: serge.mignani@rp-rorer.fr
Further Information

Publication History

Publication Date:
31 December 1999 (online)

Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a-d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.