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Synlett 1999; 1999(2): 189-192
DOI: 10.1055/s-1999-2578
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A Convenient Synthetic Route To Macrocyclic cis-3-Phenylproline Derivatives as Mimics of Sandostatin®

Dominique Damour* , Gilles Doerflinger, Guy Pantel, Richard Labaudinière, Jean-Pierre Leconte, Serge Sablé, Marc Vuilhorgne, Serge Mignani
  • *Rhône-Poulenc Rorer SA, Centre de Recherche de Vitry-Alfortville, 13 Quai Jules Guesde-BP 14, 94403, Vitry-sur-Seine Cedex, France; Fax 33(1)55 71 80 63; E-mail: serge.mignani@rp-rorer.fr
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Publication History

Publication Date:
31 December 1999 (online)

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Enantiomerically pure 14- and 20-membered cyclic proline derivatives 2a-d were conveniently prepared from cis-3-phenylproline using macrolactonisation or macrolactamisation reactions.

3-phenylprolines - cyclic prolines - macrocyclisation - lactonisation - lactamisation