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Planta Med 1999; 65(7): 595-599
DOI: 10.1055/s-1999-14030
Original Paper

Georg Thieme Verlag Stuttgart · New York

Aggregation Inhibitory Activity of Minor Acetophenones from Paeonia Species

Hang-Ching Lin1 , Hsiou-Yu Ding2 , Feng-Nien Ko3 , Che-Ming Teng3 , Yang-Chang Wu4
  • 1 School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
  • 2 Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan
  • 3 Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 4 Graduate Institute of Natural Products, Kaoshiung Medical College, Kaohsiung, Taiwan
Further Information

Publication History

January 4, 1999

May 15, 1999

Publication Date:
31 December 1999 (online)

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Abstract:

Two minor acetophenones, 2,5-dihydroxy-4-methoxyacetophenone ( 2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD 2 from arachidonic acid.

Key words:

Acetophenones - Paeonia species - Paeoniaceae - Antiplatelet aggregation