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Planta Med 1999; 65(4): 340-342
DOI: 10.1055/s-1999-13998
Original Paper

Georg Thieme Verlag Stuttgart · New York

Calcium Influx Inhibition: Possible Mechanism of the Negative Effect of Tetrahydropalmatine on Left Ventricular Pressure in Isolated Rat Heart

Paul Chan1,2 , Wen-Ta  Chiu2 , Yi-Jen  Chen1,2 , Pao-Jean  Wu3 , Juei-Tang Cheng3
  • 1Division of Cardiovascular Medicine, Taipei Medical College affiliated Taipei Wan Fang Hospital, Taiwan, R.O.C.
  • 2Clinical Research Center, Taipei Medical College, Taiwan, R.O.C.
  • 3Department of Pharmacology, College of Medicine, National Cheng-Kung University at Tainan, Taiwan, R.O.C.
Further Information

Publication History

July 22, 1998

January 9, 1999

Publication Date:
31 December 1999 (online)

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Abstract:

The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (- 45 %) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (- 39 %). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

Key words:

Calcium antagonism - cardiomyocyte - Corydalis racemosa - Papaveraceae - Langendorff - tetrahydropalmatine