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Planta Med 1999; 65(4): 320-324
DOI: 10.1055/s-1999-13994
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Effect of Several Sesquiterpene Lactones on Lipid Peroxidation and Glutathione Level

Jadwiga Jodynis-Liebert1 , Marek Murias1 , Elżbieta Błoszyk2
  • 1Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland
  • 2Department of Medical Plants, Karol Marcinkowski University of Medical Sciences, Poznań, Poland
Further Information

Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

Seven sesquiterpene lactones isolated from Helenium aromaticum: helenalin, mexicanin I, linifolin A, geigerinin, and from Telekia speciosa: 6α-hydroxy-2,3-dihydroaromaticin, asperilin, telekin have been tested for their hydroxyl radical scavenging activity and effect on lipid peroxidation. All compounds were found to be potent hydroxyl radical scavengers but did not affect lipid peroxidation in vitro. In vivo they exerted pro-oxidative properties and caused glutathione level depletion and elevation in glutathione peroxidase activity.

Key words

Sesquiterpene lactones - Helenium aromaticum - Telekia speciosa - Compositae - lipid peroxidation - hydroxyl radical scavenging - glutathione depletion