Download PDF
Handchir Mikrochir Plast Chir 1999; 31(2): 102-106
DOI: 10.1055/s-1999-13504
Originalarbeit
Hippokrates Verlag Stuttgart

Experimental Use of Prosthetic Grafts in Microvascular Surgery

Experimentelle Anwendung von synthetischen Prothesen in der mikrovaskulären ChirurgieEfterpi C. Demiri, S. L. Iordanidis, C. F. Mantinaos
  • From the Department of Plastic Surgery, Aristotle University of Thessaloniki, “G. Gennimatas” General Hospital, Thessaloniki, Greece
Further Information

Publication History

31.10.1998

Publication Date:
31 December 1999 (online)

Also available at
  PDF Download  Permissions and Reprints

Zusammenfassung

Synthetische Mikrogefäßinterponate zur Überbrückung von Gefäßdefekten wären hilfreich in der Wiederherstellungschirurgie. Wir untersuchten im Tierexperiment das Verhalten von Polytetrafluoroethylen(PTFE)-Interponaten im Vergleich zu autologen Venentransplantaten. PTFE-Prothesen von 1 mm Innendurchmesser und 10 mm Länge wurden in die Arteria femoralis des Kaninchens implantiert. Die Durchgängigkeit wurde mit der Doppier-Methode kontrolliert und alle Prothesen histologisch untersucht. Die Durchgängigkeitsrate der synthetischen Prothesen war nach vier Wochen mit 25% wesentlich niedriger (p < 0,0001) als in der autologen Kontrollgruppe.

Abstract

Interpositional microvascular grafts are very often required in reconstructive surgery for bridging microvascular defects, particularly in association with replantation of amputated segments and free tissue transplantation. The present experimental study was undertaken to evaluate patency and healing of small-diameter polytetrafluoroethylene (PTFE) prostheses and to compare them with those of microvenous grafts. 10-mm long micro-arterial PTFE grafts of 1 mm internal diameter were implanted into the femoral artery of the rabbit to restore vascular continuity. Patency was assessed by Doppier ultrasound up to four weeks postoperatively. After harvesting, all grafts were evaluated macroscopically and examined by light and transmission electron microscopy. According to our results, five of 20 re-explored PTFE grafts (25%) remained patent at four weeks, while all microvenous grafts were judged to be patent at the same time. The difference between patency rates was found to be statistically significant (p < 0.0001). Recent literature on the experimental use of microvascular prostheses is reviewed and various factors affecting graft patency are discussed.

Schlüsselwörter

Mikrochirurgie - Venentransplantate - Mikrogefäßprothesen - Intima-Hyperplasie -

Key words

Microsurgery - microvenous grafts - microvascular prostheses - intimal hyperplasia

      >