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Synthesis 1998; 1998(1): 67-70
DOI: 10.1055/s-1998-1998
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An Efficient Synthesis of N-Methylamino Acids and Some of Their Derivatives

Jan Spengler* , Klaus Burger
  • *Department of Organic Chemistry, University of Leipzig, Talstr. 35, D-04103 Leipzig, Germany; Fax + 49(3 41)9 73 65 99; E-mail: burger@organic.orgchem.uni-leipzig.de
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Publication History

Publication Date:
31 December 2000 (online)

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N-Methylamino acid derivatives are obtained in high yield by a stereoselective one-pot procedure from hexafluoroacetone protected amino acids via N-chloromethylation and treatment with triethylsilane/trifluoroacetic acid.

hexafluoroacetone - N-chloromethylation - triethylsilane - N-methylamino acids - N-methylamino derivatives