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Synlett 1998; 1998(12): 1311-1312
DOI: 10.1055/s-1998-1984
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NiCl2/CrCl2-Mediated Coupling Reaction of Ketones with Alkenyl(or Alkynyl, Aryl) Halides Accomplished in the Presence of a Bipyridyl-Type Ligand

Chinpiao Chen*
  • *Department of Medical Technology, Tzu Chi College of Medicine and Humanities, Hualien, 970, Taiwan, Republic of China; Fax 886 3 8 57 49 65; E-mail: chinpiao@cc.tcu.edu.tw
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Publication History

Publication Date:
31 December 2000 (online)

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In this work, alkenyl halides (or triflates) and alkynyl (or aryl) halides are readily coupled with ketones in tetrahydrofuran in the presence of ligand 1, NiCl2 and CrCl2 at room temperature subsequently yielding the corresponding allylic alcohols, propargylic alcohols and benzylic alcohols.

NiCl2/CrCl2-mediated - Barbier-like reaction - allylic alcohols - propargylic alcohols - benzylic alcohols