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Synlett 1998; 1998(8): 847-848
DOI: 10.1055/s-1998-1821
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Asymmetric Synthesis XXVIII: Novel Chiral Aminophosphine Phosphinite Ligand and Its Application in Homogenous Catalytic Asymmetric Hydrogenation of Dehydroamino Acid Derivatives

Aiqiao Mi* , Rongliang Lou, Yaozhong Jiang, Jingen Deng, Yong Qin, Fangmin Fu, Zhi Li, Wenhao Hu, Albert S. C. Chan
  • *Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 61 00 41, China; Fax (00 86) (0 28) 5 22 39 78; E-mail: clf@mail.sc.cninfo.net
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Publication Date:
31 December 2000 (online)

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Novel chiral aminophosphine phosphinite, DPAMPP was designed and synthesized from (1S,2R)-1,2-diphenyl-2-aminomethanol. Its cationic rhodium complex has been found to be an excellent catalyst for enantioselective hydrogenation of dehydroamino acids (more than 95.0% e.e.).

chiral aminophosphine phosphinite ligand - catalytic asymmetric hydrogenation - optically active amino acid derivatives