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Synlett 1998; 1998(8): 930-932
DOI: 10.1055/s-1998-1819
DOI: 10.1055/s-1998-1819
letter
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Synthesis of Optically Active Cyclopenta[b]benzofuran as a Precursor of m-Phenyleneprostacyclin
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199808/lookinside/thumbnails/10.1055-s-1998-1819-1.jpg)
The optically pure cyclopenta[b]benzofuran derivatives (-)-1 and (-)-2 were synthesized from (+)-(1S,4R)-cis-4-acetoxy-2-cyclopenten-1-ol [(+)-3] via sequential Mitsunobu reaction and palladium-catalyzed allylic substitution with phenol derivatives followed by SN2′ intramolecular cyclization.
cyclopentabenzofuran - prostacyclin - Mitsunobu reaction - palladium-catalyzed allylic etherification - enantioselective reaction