Download PDF
Synlett 1998; 1998(8): 817-827
DOI: 10.1055/s-1998-1813
new tools in synthesis
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Solid Phase Synthesis

Angus R. Brown* , Pedro H. H. Hermkens, Harry C. J. Ottenheijm, David C. Rees
  • *Scientific Development Group, Organon Laboratoires Ltd., Newhouse, Lanarkshire ML1 5SH, Scotland, UK
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download Permissions and Reprints All articles of this category

Solid phase synthesis is a rapidly expanding area of synthetic chemistry which has been concerned with the synthesis of diverse collections of "drug-like" molecules for use in the drug discovery process. The aim of this review is to introduce the basic concepts and practices of solid phase synthesis to the synthetic chemist. This includes choice of support, linker, development of the synthetic route, reaction monitoring and basic experimental aspects for carrying out reactions on the solid phase. These points are illustrated with the aid of some recent examples from the literature.

combinatorial chemistry - supports - linkers - equipment

      >