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Synlett 1998; 1998(8): 828-830
DOI: 10.1055/s-1998-1805
DOI: 10.1055/s-1998-1805
letter
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Synthesis of β-ketophosphonates from Thioester Intermediates: A Stereocontrolled Route to the C29,C35 Fragment of the Halichondramides
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Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199808/lookinside/thumbnails/10.1055-s-1998-1805-1.jpg)
An efficient synthesis of β-ketophosphonates from t-butyl thioesters using the lithium anion of either methane- or ethanephosphonate is described. The elaboration of a range of substrates to intermediates in natural product syntheses via the Horner Wadsworth Emmons reaction is then discussed.
thioesters - anti-aldol - β-ketophosphonate - Horner Wadsworth - Emmons reaction