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Synlett 1998; 1998(7): 751-753
DOI: 10.1055/s-1998-1771
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Entry into Erythromycin Lactams: Synthesis of Erythromycin A Lactam Enol Ether as a Potential Gastrointestinal Prokinetic Agent

Ramin Faghih* , Carla M. Edwards, Leslie A. Freiberg, Hugh N. Nellans
  • *Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, IL 60064-3500, U.S.A.; Fax (847) 9 38-10 21; E-mail: ramin.faghih@abbott.com
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Publication History

Publication Date:
31 December 2000 (online)

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The macrolactam analog of erythromycin A enol ether, compound 8, was synthesized by a two-step reaction sequence in 75% overall yield starting from erythromycin A ring contracted enol ether (4).

erythromycin A - erythromycin A enol ether - erythromycin A lactam enol ether - motilide - Martin sulfurane