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Synlett 1998; 1998(6): 609-610
DOI: 10.1055/s-1998-1748
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Incorporation of α-Substituted Serine Analog into Peptide via a Novel O,N-Migration

M. Horikawa* , T. Nakajima, Y. Ohfune
  • *Suntory Institute for Bioorganic Research, Shimamoto-cho, Mishima-gun, Osaka 618, Japan; Fax 81-75-962-2115; E-mail: LEE05541@niftyserve.or.jp
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Publikationsdatum:
31. Dezember 2000 (online)

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Peptides incorporating β-hydroxy-α,α-disubstituted-α-amino acids, (S)-α-methylserine ((S)-α-MeSer), (1R,2S)-1-amino-2-hydroxy-cyclohexanecarboxylic acid ((1R,2S)-Ahh), or (R)-α-benzyl-serine ((R)-α-BnSer), were efficiently synthesized using a novel O,N-migration.

O,N-migration - acyl migration - α-substituted serine - peptide synthesis