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Synlett 1998; 1998(5): 528-530
DOI: 10.1055/s-1998-1708
DOI: 10.1055/s-1998-1708
letter
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Homologation of 1-(Benzyloxymethyl)-1H-tetrazole via Lithiation
Further Information
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/synlett/199805/lookinside/thumbnails/10.1055-s-1998-1708-1.jpg)
Lithiation of 1-(Benzyloxymethyl)-1H-tetrazole, prepared by alkylation of 1H-tetrazole with benzyl chloromethyl ether, followed by treatment with a variety of electrophiles afforded its homologation products. Hydrogenation or acid hydrolysis gave the corresponding free tetrazoles.
1-(benzyloxymethyl)-1H-tetrazole - BOM - 5-lithiotetrazole - 5-(hydroxyalkyl)tetrazole - deprotection