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Synlett 1998; 1998(5): 510-512
DOI: 10.1055/s-1998-1688
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Efficient Access to Aminoalcohols and N-Alkyl-3-Azetidinols

Thierry Constantieux* , Stéphane Grelier, Jean-Paul Picard
  • *Laboratoire de Chimie Organique et Organométallique (URA 35 CNRS), Université Bordeaux I, 33405 Talance, France; Fax (33)556 846 646; E-mail: j-p.picard@lcoo.u-bordeaux.fr
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Publikationsdatum:
31. Dezember 2000 (online)

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Regioselective aminolysis of various 1,2-epoxides with 1-(trimethylsilyl)alkylamines leading to an efficient preparation of the corresponding N-substituted β-aminoalcohols is reported. The reaction has been extended to the synthesis of a new class of N-alkyl-3-azetidinols.

aminolysis - 1-(trimethylsilyl)alkylamines - 1,2-epoxides - β-aminoalcohols - epichlorohydrin - 3-azetidinols