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Synlett 1998; 1998(4): 407-410
DOI: 10.1055/s-1998-1674
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Aromatic Ring Opening of Fused Thiophenes via Organolithium Addition to Sulfur

B. Hill* , M. De Vleeschauwer, K. Houde, M. Belley
  • *Merck Frosst Centre for Therapeutic Research, Department of Medicinal Chemistry, 16711 Route Transcanadienne, Kirkland, Québec, H9H 3L1, Canada; Fax (514)4 28-49 36; E-mail: belley@merck.com
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Publikationsdatum:
31. Dezember 2000 (online)

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Organolithium reagents can add to the sulfur atom of thiophenes that are substituted by a chlorine atom and fused to another aromatic system, at -78 °C, to give ortho-substituted aryl sulfides.

thiophenes - ring opening - thieno[3,2-d]thiazole - benzo[b]thiophene - fused thiophenes

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