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Synlett 1998; 1998(2): 131-132
DOI: 10.1055/s-1998-1615
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Direct Preparation of Saccharin Skeletons from N-Methyl(o-methyl)arenesulfonamides with (Diacetoxyiodo)arenes

Hideo Togo* , Masashi Katohgi, Masataka Yokoyama
  • *Department of Chemistry, Faculty of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263, Japan; Fax 043 290 2874; E-mail: octogo@science.s.chiba-u.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Various N-methylsaccharins were easily prepared in moderate to good yields by the reaction of N-methyl(o-methyl)arenesulfonamides with (diacetoxyiodo)arene in the presence of iodine under irradiation with a tungsten lamp. The present method is very useful for the direct preparation of saccharins with N-methyl(o-methyl)arenesulfonamides containing various substituents on the aromatic ring.

N-methylsaccharins - (diacetoxyiodo)arenes - sulfonamidyl radical