Download PDF
Synlett 1997; 1997(3): 325-326
DOI: 10.1055/s-1997-769
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Combinatorial Synthesis of C(2), C(3)-Disubstituted 3-Hydroxypropionamides Utilizing Baylis-Hillman Reactions on Solid Support

O. Prien, K. Rölfing, M. Thiel, H. Künzer*
  • *Research Laboratories, Schering AG-Berlin, Müllerstr. 170-178, D-13342 Berlin, Germany
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A four-step reaction protocol for multiple polymer-supported synthesis of structurally diverse α,β-disubstituted 3-hydroxypropionamides 10 has been developed. Variable building blocks were recruited from three monomer pools: primary/secondary amines and aryl aldehydes, the latter of which underwent incorporation into target molecules via Baylis-Hillman reactions. The potential of our approach is demonstrated by machine-assisted assemblage of a small prototype library.

multi-step solid-phase synthesis - combinatorial chemistry - Baylis-Hillman reaction - robot-assisted synthesis

      >