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Synlett 1997; 1997(2): 199-201
DOI: 10.1055/s-1997-753
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Enantioselective Synthesis of Aurilide, a Cytotoxic 26-Membered Cyclodepsipeptide of Marine Origin

Tsuyoshi Mutou, Kiyotake Suenaga, Tatsuya Fujita, Takashi Itoh, Noboru Takada, Kozue Hayamizu, Hideo Kigoshi, Kiyoyuki Yamada*
  • *Department of Chemistry, Faculty of Science, Nagoya University, Chikusa, Nagoya 464, Japan, Fax +81 52 789 5041; e-mail yamada@chem3.chem.nagoya-u.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Aurilide (1), a novel cyclodepsipeptide isolated from the Japanese sea hare Dolabella auricularia, was enantioselectively synthesized, and the present result unambiguously confirmed its stereostructure. In addition, the cytotoxicity of 1 was evaluated by employing synthetic 1.

aurilide - cytotoxic 26-membered cyclodepsipeptide - enantioselective synthesis - anti aldol reaction - macrolactamization

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